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横尾 宏毅


氏名 横尾 宏毅 (YOKOO Hiroki)
所属 常葉大学 健康プロデュース学部 健康栄養学科
職名 大学院健康科学研究科長
学位 博士(医学)
専門分野 薬理学、分子生物学、神経科学
主な担当科目 人体構造・機能論Ⅱ&Ⅲ、人体構造・機能実習、病態生理学、臨床検査学実習、臨床栄養チーム医療論、精神薬理学特論
researchmap https://researchmap.jp/rread0072772(別ウィンドウで開きます)

メッセージ

科学および栄養学を勉強したことをベースにして、国民一人一人の健康な体をプロデュースしていくことに貢献していきましょう。

主な研究業績および社会貢献活動など

  • Yamashita S, Suzuki T, Iguchi K, Sakamoto T, Tomita K, Yokoo H, Sakai M, Misawa H, Hattori K, Nagata T, Watanabe Y, Matsuda N, Yoshimura N, Hattori Y: Cardioprotective and functional effects of levosimendan and milrinone in mice with cecal ligation and puncture-induced sepsis. Naunyn Schmiedebergs Arch Pharmacol, in press.
  • Kawakami M, Hattori M, Ohashi W, Fujimori T, Hattori K, Takebe M, Tomita K, Yokoo H, Matsuda N, Yamazaki M, Hattori Y: Role of G protein-coupled receptor kinase 2 in oxidative and nitrosative stress-related neurohistopathological changes in a mouse model of sepsis-associated encephalopathy. J Nurochem, 145(6):474-488, 2018.
  • Qiang W, Yokoo H, Takashina M, Sakata K, Ohashi W, Abedelzaher LA, Imaizumi T, Sakamoto T, Hattori K, Matsuda N, Hattori Y: Anti-inflammatory profile of levosimendan in cecal ligation-induced septic mice and in lipopolysaccharide-stimulated macrophages. Crit Care Med 43:e508-e520, 2015.
  • Sakata K, Kondo T, Mizuno N, Shoji M, Yasui H, Yamamori T, Inanami O, Yokoo H, Yoshimura N, Hattori Y: Roles of ROS and PKC-betaII in ionizing radiation-induced eNOS activation in human vascular endothelial cells. Vascul Pharmacol, 70:55-65, 2015.
  • Yokoo H, Chiba S, Tomita K, Takashina M, Sagara H, Yagisita S, Takano Y, Hattori Y: Neurodegenerative evidence in mice brains with cecal ligation and puncture-induced sepsis: preventive effect of the free radical scavenger edaravone. PLoS One, 7:e51539, 2012.
  • Kageyama S, Yokoo H, Tomita K, Kageyama-Yahara N, Uchimido R, Matsuda N, Yamamoto S, Hattori Y: High glucose-induced apoptosis in human coronary artery endothelial cells involves up-regulation of death receptors. Cardiovasc Diabetol, 10:73, 2011.
  • Zhang XH, Yokoo H, Nishioka H, Fujii H, Matsuda N, Hayashi T, Hattori Y: Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells. Br J Pharmacol, 159:928-938, 2010.
  • Yokoo H, Nemoto T, Yanagita T, Satoh S, Yoshikawa N, Maruta T, Wada A: Glycogen synthase kinase-3β: homologous regulation of cell surface insulin receptor level via controlling insulin receptor mRNA stability in adrenal chromaffin cells. J Neurochem, 103:1883-1896, 2007.
  • Nemoto T, Yokoo H, Satoh S, Yanagita T, Sugano T, Yoshikawa N, Maruta T, Kobayashi H, Wada A: Constitutive activity of glycogen synthase kinase-3β: positive regulation of steady-state levels of insulin receptor substrates-1 and -2 in adrenal chromaffin cells. Brain Res, 1110:1-12, 2006.
  • Yokoo H, Saitoh T, Shiraishi S, Yanagita T, Sugano T, Minami S, Kobayashi H, Wada A: Distinct effects of ketone bodies on down-regulation of cell surface insulin receptor and insulin receptor substrate-1 phosphorylation in adrenal chromaffin cells. J Pharmacol Exp Ther, 304:994-1002, 2003.

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