グローバルナビゲーションへ

本文へ

ローカルナビゲーションへ

フッターへ



教員情報


横尾 宏毅

職名教授/健康科学研究科長
所属常葉大学 健康プロデュース学部 健康栄養学科
学位博士(医学)
研究分野  薬理学、神経科学、分子生物学

学歴

  • 1983年 3月 熊本県立熊本高等学校卒業
  • 1985年 4月 宮崎医科大学医学部医学科入学
  • 1991年 3月 同上卒業
  • 1995年 4月 宮崎医科大学大学院医学研究科博士課程入学
  • 1999年 3月 同上修了
  • 1999年 4月 宮崎医科大学医学部研究生入学
  • 2000年 9月 同上退学

職歴

  • 1991年 6月 宮崎医科大学医学部附属病院医員(麻酔科)
  • 1991年10月 宮崎県立宮崎病院(麻酔科)
  • 1992年 9月 宮崎医科大学医学部附属病院医員(麻酔科)
  • 1993年 7月 市立川西病院(兵庫県川西市)医師(麻酔科)
  • 1994年 9月 財団医療法人聖十字会西日本病院(熊本市)医師(麻酔科)
  • 1995年 3月 大学院博士課程進学のため同上退職
  • 2000年10月 宮崎医科大学助手(薬理学講座)
          (上記現名称、宮崎大学医学部機能制御学講座薬理学分野)
  • 2007年10月 富山大学大学院医学薬学研究部准教授(分子医科薬理学講座)
  • 2014年 9月 常葉大学健康プロデュース学部健康栄養学科教授
          現在に至る

担当科目

人体構造・機能論II、人体構造・機能論III、人体構造・機能実験
病態生理学、臨床検査学実習、臨床栄養チーム医療論、管理栄養士専門演習、人間力セミナー

資格・免許

  • 1991年 5月 医師免許取得(医籍登録第342838号)
  • 1994年 1月 麻酔科標榜許可(登録第6769号)
  • 1999年 3月 医学博士(宮崎医科大学博甲194号)

論文

  • Yamamoto R, Yanagita T, Kobayashi H, Yuhi T, Yokoo H, Wada A: Up-regulation of functional voltage-dependent sodium channels by insulin in cultured bovine adrenal chromaffin cells. J Neurochem, 67:1401-1408, 1996
  • Yamamoto R, Yanagita T, Kobayashi H, Yokoo H, Wada A: Up-regulation of sodium channel subunit mRNAs and their cell surface expression by antiepileptic valproic acid: activation of calcium channel and catecholamine secretion in adrenal chromaffin cells. J Neurochem, 68:1655-1662, 1997
  • Yokoo H, Shiraishi S, Kobayashi H, Yanagita T, Yamamoto R, Wada A: Selective inhibition by riluzole of voltage-dependent sodium channels and catecholamine secretion in adrenal chromaffin cells. Naunyn Schmiedebergs Arch Pharmacol, 357:526-531, 1998
  • Yanagita T, Kobayashi H, Yamamoto R, Takami Y, Yokoo H, Yuhi T, Nakayama T, Wada A: Protein kinase C and the opposite regulation of sodium channel α- and β1-subunit mRNA levels in adrenal chromaffin cells. J Neurochem, 73:1749-1757, 1999
  • Yanagita T, Kobayashi H, Yamamoto R, Kataoka H, Yokoo H, Shiraishi S, Minami S, Koono M, Wada A: Protein kinase C-α and -ε down-regulate cell surface sodium channels via differential mechanisms in adrenal chromaffin cells. J Neurochem, 74:1674-1684, 2000
  • Yamamoto R, Kobayashi H, Yanagita T, Yokoo H, Kurose T, Shiraishi S, Minami S, Matsukura S, Wada A: Up-regulation of cell surface insulin receptor by protein kinase C-α in adrenal chromaffin cells: involvement of transcriptional and translational events. J Neurochem, 75:672-682, 2000
  • Yokoo H, Shiraishi S, Kobayashi H, Yanagita T, Minami S, Yamamoto R, Wada A: Inhibition by neuroprotective drug NS-7 of nicotine-induced 22Na+ influx, 45Ca2+ influx and catecholamine secretion in adrenal chromaffin cells. Brain Res, 873:149-154, 2000
  • Yanagita T, Yamamoto R, Sugano T, Kobayashi H, Uezono Y, Yokoo H, Shiraishi S, Minami S, Wada A: Adrenomedullin inhibits spontaneous and bradykinin-induced but not oxytocin- or prostaglandin F2α-induced periodic contraction of rat uterus. Br J Pharmacol, 130:1727-1730, 2000
  • Yokoo H, Kobayashi H, Minami S, Shiraishi S, Yamamoto R, Yanagita T, Tsuchiya K, Mohri M, Wada A: α1-Adrenergic receptor subtypes in rat cerebral microvessels. Brain Res, 878:183-187, 2000
  • Yokoo H, Shiraishi S, Kobayashi H, Yanagita T, Minami S, Yamamoto R, Wada A: Short- and long-term differential effects of neuroprotective drug NS-7 on voltage-dependent sodium channels in adrenal chromaffin cells. Br J Pharmacol, 131:779-787, 2000
  • Shiraishi S, Yokoo H, Kobayashi H, Yanagita T, Uezono Y, Minami S, Takasaki M, Wada A: Post-translational reduction of cell surface expression of insulin receptors by cyclosporin A, FK506 and rapamycin in bovine adrenal chromaffin cells. Neurosci Lett, 293:211-215, 2000
  • Kobayashi H, Minami S, Itoh S, Shiraishi S, Yokoo H, Yanagita T, Uezono Y, Mohri M, Wada A: Aquaporin subtypes in rat cerebral microvessels. Neurosci Lett, 297:163-166, 2001
  • Kobayashi H, Shiraishi S, Minami S, Yokoo H, Yanagita T, Saitoh T, Mohri M, Wada A: Adrenomedullin receptors in rat choroid plexus. Neurosci Lett, 297:167-170, 2001
  • Kobayashi H, Yamamoto R, Kitamura K, Kuwasako K, Minami S, Yanagita T, Shiraishi S, Yokoo H, Eto T, Wada A: Selective inhibition of nicotinic cholinergic receptors by proadrenomedullin N-terminal 12 peptide in bovine adrenal chromaffin cells. Brain Res Mol Brain Res, 87:175-183, 2001
  • Shiraishi S, Shibuya I, Uezono Y, Yokoo H, Toyohira Y, Yamamoto R, Yanagita T, Kobayashi H, Wada A: Heterogeneous increases of cytoplasmic calcium: distinct effects on down-regulation of cell surface sodium channels and sodium channel subunit mRNA levels. Br J Pharmacol, 132:1455-1466, 2001
  • Shiraishi S, Yamamoto R, Yanagita T, Yokoo H, Kobayashi H, Uezono Y, Wada A: Down-regulation of cell surface insulin receptors by sarco(endo)plasmic reticulum Ca2+-ATPase inhibitor in adrenal chromaffin cells. Brain Res, 898: 152-157, 2001
  • Shiraishi S, Yanagita T, Kobayashi H, Uezono Y, Yokoo H, Minami S, Takasaki M, Wada A: Up-regulation of cell surface sodium channels by cyclosporin A, FK506, and rapamycin in adrenal chromaffin cells. J Pharmacol Exp Ther, 297:657-665, 2001
  • Minami S, Kobayashi H, Yamashita A, Yanagita T, Uezono Y, Yokoo H, Shiraishi S, Saitoh T, Asada Y, Komune S, Wada A: Selective expression of aquaporin 1, 4 and 5 in the rat middle ear. Hear Res, 158:51-56, 2001
  • Uezono Y, Nakamura E, Ueda Y, Shibuya I, Ueta Y, Yokoo H, Yanagita T, Toyohira Y, Kobayashi H, Yanagihara N, Wada A: Production of cAMP by adrenomedullin in human oligodendroglial cell line KG1C: comparison with calcitonin gene-related peptide and amylin. Brain Res Mol Brain Res, 97:59-69, 2001
  • Saitoh T, Yanagita T, Shiraishi S, Yokoo H, Kobayashi H, Minami S, Onitsuka T, Wada A: Down-regulation of cell surface insulin receptor and insulin receptor substrate-1 phosphorylation by inhibitor of 90-kDa heat-shock protein family: endoplasmic reticulum retention of monomeric insulin receptor precursor with calnexin in adrenal chromaffin cells. Mol Pharmacol, 62:847-855, 2002
  • Yokoo H, Saitoh T, Shiraishi S, Yanagita T, Sugano T, Minami S, Kobayashi H, Wada A: Distinct effects of ketone bodies on down-regulation of cell surface insulin receptor and insulin receptor substrate-1 phosphorylation in adrenal chromaffin cells. J Pharmacol Exp Ther, 304:994-1002, 2003
  • Shiraishi S, Yokoo H, Yanagita T, Kobayashi H, Minami S, Saitoh T, Takasaki M, Wada A: Differential effects of bupivacaine enantiomers, ropivacaine and lidocaine on up-regulation of cell surface voltage-dependent sodium channels in adrenal chromaffin cells. Brain Res, 966:175-184, 2003
  • Yanagita T, Kobayashi H, Uezono Y, Yokoo H, Sugano T, Saitoh T, Minami S, Shiraishi S, Wada A: Destabilization of Nav1.7 sodium channel α-subunit mRNA by constitutive phosphorylation of extracellular signal-regulated kinase: negative regulation of steady-state level of cell surface functional sodium channels in adrenal chromaffin cells. Mol Pharmacol, 63:1125-1136, 2003
  • Kobayashi H, Itoh S, Yanagita T, Yokoo H, Sugano T, Wada A: Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in PC12 cells after exposure to nerve growth factor. Neuroscience, 125:973-980, 2004
  • Sugano T, Yanagita T, Yokoo H, Satoh S, Kobayashi H, Wada A: Enhancement of insulin-induced PI3K/Akt/GSK-3β and ERK signaling by neuronal nicotinic receptor/PKC-α/ERK pathway: up-regulation of IRS-1/-2 mRNA and protein in adrenal chromaffin cells. J Neurochem, 98:20-33, 2006
  • Nemoto T, Yokoo H, Satoh S, Yanagita T, Sugano T, Yoshikawa N, Maruta T, Kobayashi H, Wada A: Constitutive activity of glycogen synthase kinase-3β: positive regulation of steady-state levels of insulin receptor substrates-1 and -2 in adrenal chromaffin cells. Brain Res, 1110:1-12, 2006
  • Kobayashi H, Yokoo H, Yanagita T, Satoh S, Kis B, Deli M, Niwa M, Wada A: Induction of aquaporin 1 by dexamethasone in lipid rafts in immortalized brain microvascular endothelial cells. Brain Res, 1123:12-19, 2006
  • Yokoo H, Nemoto T, Yanagita T, Satoh S, Yoshikawa N, Maruta T, Wada A: Glycogen synthase kinase-3β: homologous regulation of cell surface insulin receptor level via controlling insulin receptor mRNA stability in adrenal chromaffin cells. J Neurochem, 103:1883-1896, 2007
  • Kamiyama K, Matsuda N, Yamamoto S, Takano K, Takano Y, Yamazaki H, Kageyama S, Yokoo H, Nagata T, Hatakeyama N, Tsukada K, Hattori Y: Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea pig lungs using methylprednisolone. Am J Physiol Lung Cell Mol Physiol, 295:L998-L1006, 2008
  • Matsuda N, Yamamoto S, Yokoo H, Tobe K, Hattori Y: Nuclear factor-κB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis. Crit Care Med, 37:2791-2799, 2009
  • Matsuda N, Teramae H, Futatsugi M, Takano K, Yamamoto S, Tomita K, Suzuki T, Yokoo H, Koike K, Hattori Y: Up-regulation of histamine H4 receptors contributes to splenic apoptosis in septic mice: counteraction of the antiapoptotic action of nuclear factor-κB. J Pharmaco Exp Ther, 332:730-737, 2010
  • Zhang XH, Yokoo H, Nishioka H, Fujii H, Matsuda N, Hayashi T, Hattori Y: Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells. Br J Pharmacol, 159:928-938, 2010
  • Takano K, Yamamoto S, Tomita K, Takashina M, Yokoo H, Matsuda N, Takano Y, Hattori Y: Successful treatment of acute lung injury with pitavastatin in septic mice: potential role of glucocorticoid receptor expression in alveolar macrophages. J Pharmacol Exp Ther, 336: 381-390, 2011
  • Kageyama S, Yokoo H, Tomita K, Kageyama-Yahara N, Uchimido R, Matsuda N, Yamamoto S, Hattori Y: High glucose-induced apoptosis in human coronary artery endothelial cells involves up-regulation of death receptors. Cardiovasc Diabetol, 10:73, 2011
  • Oishi H, Takano K, Tomita K, Takebe M, Yokoo H, Yamazaki M, Hattori Y: Olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through CREB-independent activation of the Akt pathway. Am J Physiol Lung Cell Mol Physiol, 303:L130-L140, 2012
  • Yokoo H, Chiba S, Tomita K, Takashina M, Sagara H, Yagisita S, Takano Y, Hattori Y: Neurodegenerative evidence in mice brains with cecal ligation and puncture-induced sepsis: preventive effect of the free radical scavenger edaravone. PLoS One, 7:e51539, 2012

著書

  • Wada A, Kobayashi H, Yamamoto R, Yanagita T, Yuhi T, Yokoo H: Modulation of voltage-dependent sodium channel subunit mRNAs and their cell surface expression by extra- and intra-cellular signals. In: The Adrenal Chromaffin Cell. T. Kanno et al(eds). Hokkaido Univ. Press, Sapporo, pp261-270, 1998
  • 横尾宏毅:コメディカルのための薬理学 改訂第2版,第3章(1-12項)中枢神経系に作用する薬物,渡邊泰秀,樋口マキヱ(編),朝倉書店,東京,60-77頁,2012

所属学会

1991年 6月 日本麻酔学会 会員
1995年 7月 日本薬理学会 会員
2012年 7月 Member of the American Society for Pharmacology and Experimental  Therapeutics (ASPET)
2012年10月 日本循環薬理学会 会員

スポーツ実績・指導歴

2003年10月~2007年 9月 宮崎大学柔道部監督

メッセージ

サイエンスを勉強かつその知識をもとに、国民一人一人の健康な体をプロデュースしていくことに貢献していきましょう。