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教員情報


小田 敏明

職名教授/健康柔道整復学科長/副学生部長
所属常葉大学 健康プロデュース学部 健康柔道整復学科
学位理学博士
研究分野  生化学、細胞生物学、分子生物学

学歴

1973年 九州大学理学部生物学科 卒業
1975年 九州大学大学院理学研究科修士課程(生物学専攻) 修了
1980年 九州大学大学院理学研究科博士課程(生物学専攻) 修了(理学博士号取得)

経歴

1979年 浜松医科大学生化学第一教室 助手
1983年 文部科学省流動 研究員(京都大学医学部)
1989年 Research Fellow (Harvard Medical School、米国)
1991年 浜松医科大学生化学第一教室 助教授(2007年より准教授)
2005年 静岡理工科大学大学院 非常勤講師

教育歴

1979年 浜松医科大学生化学第一教室 助手
1991年 浜松医科大学生化学第一教室 助教授(2007年より准教授)

受賞

2003年 フレーム(翻訳枠)調整リンカー 米国特許取得(特許番号:US 6,548,656 B1)

資格

  • 理学博士
  • 有機溶剤作業主任者

論文

1. Fukasawa, H, Yamamoto, T, Fujigaki, Y, Misaki, T, Ohashi, N, Takayama, T, Mugiya, S, Oda, T, Uchida, C, Kitagawa, K, Hattori, T, Suzuki, S, Hayashi, H, Ozono, S, Kitagawa, M, Hishida, A.: Reduction of transforming growth factor-ss type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma. Int. J. Cancer, 2010, in press.

2. Nagata, M., Ichiyama, A., Takayama, T., Oda, T., Mugiya, S., and Ozono, S.: Assay of alanine:glyoxylate aminotransferase in human liver by its serine:glyoxylate aminotransferase activity. Biomed. Res., 30, 295-301, 2009.

3. Isobe, T., Hattori, T., Kitagawa, K., Uchida, C., Kotake, Y., Kosugi, I., Oda, T. and Kitagawa, M.: Adenovirus E1A inhibits SCF-Fbw7 ubiquitin ligase. J Biol Chem. 284, 27766-27779, 2009.

4. Misaki, T., Yamamoto,T., Suzuki, S., Fukasawa, H., Togawa, A., Ohashi, N., Suzuki, H., Fujigaki, Y., Oda, T., Uchida, C., Kitagawa, K., Hattori, T., Kitagawa, M., and Hishida, A. : Decrease in tumor necrosis factor-a receptor-associated death domain results from ubiquitin-dependent degradation in obstructive renal injury in rats. Am. J. Pathol. 175, 74-83, 2009.

5. Kitagawa, K., Hiramatsu, Y., Uchida, C., Isobe, T., Hattori, T., Oda, T., Shibata, K. ,Nakamura, S., Kikuchi A. and Kitagawa, M. :Fbw7 promotes ubiquitin-dependent degradation of c-Myb :Involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb. Oncogene, 28, 2393-2405, 2009.

6. Shimada, M., Kitagawa, K., Dobashi, Y., Isobe, T., Hattori, T., Uchida, C., Abe, K., Kotake, Y., Oda, T., Suzuki, H., Hashimoto, K., and Kitagawa, M.: High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers. Cancer Science 100 (5), 866-872, 2009

7. Abe, K., Hattori, T., Isobe, T., Kitagawa, K., Oda, T., Uchida, C., and Kitagawa, M.: Pirh2 interacts with and ubiquitylates signal recognition particle receptor b subunit. Biomed. Res., 29, 53-60, 2008.

8. Hattori, T., Isobe, T., Abe, K., Kikuchi, H., Kitagawa, K., Oda, T., Uchida, C. and Kitagawa, M.: Pirh2 Promotes Ubiquitin-Dependent Degradation of the CDK Inhibitor p27Kip1. Cancer Res. 67, 10789-10795, 2007.

9. Suzuki, S., Fukasawa, H., Kitagawa, K., Uchida, C., Hattori, T., Isobe,T., Oda, T., Misaki, T., Ohashi, N., Nakayama, K., Nakayama, K.I., Hishida, A., Yamamoto, T. and Kitagawa, M.: Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice. Am. J. Pathol, 171, 473-483, 2007.

10. Kikuchi, H., Uchida, C., Hattori, T., Isobe, T., Hiramatsu, Y., Kitagawa, K., Oda, T., Konno, H. and Kitagawa, M.: ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells. Carcinogenesis, 28,1752-1758, 2007.

11. Kono, S., Suzuki, H., Oda, T., and Miyajima, H.: Biochemical features of ceruloplasmin gene mutations linked to aceruloplasminemia. Neuromol. Med., 8, 361-374, 2006.

12. Gao, Y., Kitagawa, K., Hiramatsu, Y., Kikuchi, H., Isobe, T., Shimada, M., Uchida, C., Hattori
, T., Oda, T.,Nakayana, K., Nakayana, K.I, Tanaka, T., Konno, H. and Kitagawa, M.: Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis. Cancer Res. 66, 11623-1163, 2006.

13. Hiramatsu, Y., Kitagawa, K., Suzuki, T., Uchida, C., Hattori, T., Kikuchi, H., Oda, T., Hatakeyama, S., Nakayama, K. I. Yamamoto., T.,Konno, H., and Kitagawa, M.: Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination. Cancer Res. 66, 8477-8483, 2006.

14. Fukasawa, H., Yamamoto, T., Togawa, A. Ohashi, N., Fujigaki, Y., Oda, T., Uchida, C., Kitagawa, K., Hattori, T., Suzuki, S., Kitagawa, M. and Hishida, A.: Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury. Kidney Int. 69, 1733-1740, 2006.

15. Uchida C., Miwa S., Isobe T., Kitagawa K., Hattori T., Oda, T., Yasuda H., and Kitagawa M. : Effect of MdmX on Mdm2-mediated downregulation of pRB. FEBS Letters 580, 1753-1758, 2006.

16. Isobe, T., Uchida, C., Hattori, T., Kitagawa, K., Oda, T. and Kitagawa, M.: Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69. Biochem Biophys Res Commun. 339, 367-374, 2006.

17. Miwa, S., Uchida, C., Kitagawa, K., Hattori, T., Oda, T., Sugimura, H., Yasuda, H., Nakamura, H. Chida K. and Kitagawa, M.: Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner. Biochem Biophys Res Commun. 430, 54-61, 2006.

18. Gao, Y., Kitagawa, K., Shimada, M., Uchida, C., Hattori, T., Oda, T. and Kitagawa, M.: Generation of a constitutively active mutant of human GPR48/LGR4, a G-protein-coupled receptor. Hokkaido. J. Med. Sci. 81, 101-109, 2006.

19. Uchida C., Miwa S., Kitagawa K., Hattori T., Isobe T., Otani S., Oda, T., Sugimura H., Kamijo T., Ookawa K., Yasuda H., and Kitagawa M. (2005): Enhanced Mdm2 activity ibhibits pRB function via ubiquitin-dependent degradation. EMBO J. 24, 160-169, 2005.

20. Ohashi, N., Yamamoto, T., Uchida, C., Togawa, A., Fukasawa, H., Fujigaki, Y., Suzuki, S., Kitagawa, K., Hattori, T., Oda, T., Hayashi, H., Hishida, A. and Kitagawa, M.: Transcriptional induction of Smurf2 ubiquitin ligase by TGF-b. FEBS Letters 579, 2557-2563, 2005.

21. Fukasawa H., Yamamoto T., Togawa A., Ohashi N., Fujigaki Y., Oda, T., Uchida C., Kitagawa K., Hattori T., Suzuki S., Kitagawa M., and Hishida A: Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in mice obstructive nephropathy. Proc. Natl. Acad. Sci.. USA, 101, 8687-8692, 2004.

22. Hattori T., Kitagawa K., Uchida C., Oda, T. & Kitagawa M.: Cks1 is degraded via the ubiquitin-proteasome pathway in a cell cycle-dependent manner. Genes to Cells. 8, 889-896, 2003.

23. Huang, Y., Ito, R., Miura, S., Yokota, S., Oda, T., & Ito, M.: Aitered antigenic disposition of peroxisomal urate oxidase in PEX5-defective Chinese hamster ovary cells. Biochem. Biophys. Res. Commun. 302, 703-709, 2003.

24. Mizuno, T., Ito, K., Uchida, C., Kitagawa, M., Ichiyama, A., Miura, S., Fujita, K. & Oda, T. : Analyses in transfected cells and in vitro of a putative peroxisomal targeting signal of rat liver serine:pyruvate aminotransferase. Histochem. Cell Biol., 118, 321-328, 2002.

25. Uchida, C., Oda, T., Sugiyama, T., Otani, S., Kitagawa, M., & Ichiyama, A.: The role of Sp1 and AP-2 in basal and protein kinase A-induced expression of mitochondrial serine:pyruvate aminotransferase in hepatocytes. J. Biol. Chem. 277, 39082-39092, 2002.

26. Sugiyama, T., Uchida, C., Oda, T., Kitagawa, M., Hayashi, H. & Ichiyama, A. : Involvement of CCAAT/enhancer-binding protein in regulation of the rat serine:pyruvate/alanine:glyoxylate aminotransferase gene expression. FEBS Lett. 508,16-22, 2001.

27. Yokota, S., Oda, T. & Fahimi, H.D : The role of 15-lipoxygenase in disruption of the peroxisomal membrane and in programmed degradation of peroxisomes in normal rat liver. J. Histochem. Cytochem., 49, 613-621, 2001.

28. Yokota, S., Kamijo, K. & Oda, T. : Aggregate formation and degradation of overexpressed wild-type and mutant urate oxidase proteins. Quality control of organelle-destined proteins by the endoplasmic reticulum. Histochem. Cell Biol., 114, 433-446, 2000.

29. Xue, H.-H., Zhao, D.-M., Suda, T., Uchida, C., Oda, T., Chida, K., Ichiyama, A., & Nakamura H. : Store Depletion by Caffeine/Ryanodine Activates Capacitative Ca2+ Entry in Nonexcitable A549 Cells. J. Biochem. 128, 329-336, 2000.

30. Oda, T., Uchida, C. & Miura S.: Mitochondrial targeting signal-induced conformational change and repression of the peroxisomal targeting signal of the precursor for rat liver serine:pyruvate/alanine:glyoxylate aminotransferase. J. Biochem. 127, 665 - 671, 2000.

31. Oda, T., Funai, T. & Ichiyama, A. : Induction by peroxisome proliferators and triiodothyronine of serine:pyruvate /alanine:glyoxylate aminotransferase of rat liver. FEBS Lett., 418, 265-268, 1997.

32. Oda, T., Funai, T. & Miura, S. : In vitro association with peroxisomes and conformational change of peroxisomal serine:pyruvate/alanine:glyoxylate aminotransferase in rat and human livers. Biophys. Biochem. Res. Commun., 228, 341-346, 1996.

33. Oda, T., Nishiyama, K. & Ichiyama, A. : Characterization and sequence analysis of rat serine:pyruvate/alanine:glyoxylate aminotransferase gene. Genomics, 17, 59-65, 1993.

34. Oda, T., Funai, T. & Ichiyama, A. : Generation from a single gene of two mRNAs that encode the mitochondrial and peroxisomal serine:pyruvate aminotransferase of rat liver. J. Biol. Chem. 265, 7513-7519, 1990.

35. Oda, T., Miyajima, H., Suzuki, Y., Ito, T., Yokota, S., Hoshino, M. & Ichiyama, A. : Purification and characterization of the active serine:pyruvate aminotransferase of rat liver mitochondria expressed in Escherichia coli. J. Biochem. 106, 460-467, 1989.

36. Oda, T., Funai, T., Miyajima, H., Suzuki, Y. & Ichiyama, A. : Biosynthesis of serine:pyruvate aminotransferase of rat liver mitochondria and peroxisomes. Biomed. Res. 8(suppl), 5-11, 1987.

37. Oda, T., Miyajima, H., Suzuki, Y. & Ichiyama, A. : Nucleotide sequence of the cDNA encoding the precursor for mitochondrial serine:pyruvate aminotransferase of rat liver. Eur. J. Biochem. 168, 537-542, 1987.

担当経験のある科目

  • 化学を学ぶ・生物を学ぶ

所属学協会

日本生化学会、日本細胞生物学会、日本分子生物学会

メッセージ

科学知識の裏付けの上に柔道整復学を習得した医療人(柔道整復師)として、社会に貢献できる人材の育成を目指しています。